// build a matrix from a transform.
var matrix = Matrix4x4();

/// Build a matrix from a transform.
function Start () {
matrix.SetColumn (0, transform.right);
matrix.SetColumn (1, transform.up);
matrix.SetColumn (2, transform.forward);
var p = transform.position;
matrix.SetColumn (3, Vector4 (p.x, p.y, p.z, 1));
}

using UnityEngine;
using System.Collections;

public class example : MonoBehaviour {
public Matrix4x4 matrix = new Matrix4x4();
void Start() {
matrix.SetColumn(0, transform.right);
matrix.SetColumn(1, transform.up);
matrix.SetColumn(2, transform.forward);
Vector3 p = transform.position;
matrix.SetColumn(3, new Vector4(p.x, p.y, p.z, 1));
}
}

import UnityEngine
import System.Collections

class example(MonoBehaviour):

public matrix as Matrix4x4 = Matrix4x4()

def Start():
matrix.SetColumn(0, transform.right)
matrix.SetColumn(1, transform.up)
matrix.SetColumn(2, transform.forward)
p as Vector3 = transform.position
matrix.SetColumn(3, Vector4(p.x, p.y, p.z, 1))